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| Product Category: | Knockdown Validated Monoclonal Antibody |
| Synonyms: | NFKB Inhibitor Alpha; NF-Kappa-B Inhibitor Alpha; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Alpha; Major Histocompatibility Complex Enhancer-Binding Protein MAD3; I-Kappa-B-Alpha; IkappaBalpha; IkB-Alpha; NFKBI; IKBA; Nuclear Factor Of Kappa Light Chain Gene Enhancer In B-Cells; EDAID2; MAD-3; MAD3 |
| UniProt Entry: | P25963 |
| NCBI Gene Entry: | 4792 |
| Molecular Weight: | 39 kDa |
| Clonality: | Mouse Monoclonal antibody |
| Species Reactivity: | Human |
| Applications: | WB/IC |
| Recommended Dilution: | Western blotting (WB): 1:1,000 Immunocytochemistry (IC): 1:100 |
| Immunogen: | Recombinant fragment of human NFKBIA |
| Isotype: | Mouse IgG |
| Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
| Storage: | At –20°C |
| Background: | NFKBIA gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. |
| Documents: | Please contact us to request the manual |
